Sample size in a prognostic study: prep (prediction of risks in early onset pre-eclampsia)
نویسندگان
چکیده
Background Significant numbers of studies struggle to recruit to target and request extension of time or additional funding. PREP is a study to develop a prediction model for adverse maternal and fetal outcomes in women with early onset pre-eclampsia. Pre-eclampsia is a condition in pregnancy associated with raised blood pressure and proteinuria and is one of the main causes of maternal and fetal mortality and morbidity. Accurate prediction of risks will aid clinicians in planning appropriate management.
منابع مشابه
Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study
Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks’ gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management. Methods: We aim to undertake a mul...
متن کاملPrediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models
BACKGROUND Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required. METHOD Women with confirmed early onset pre-eclampsia were recruited from 53 maternity units in the UK to a large prospective cohort study (PREP-946) for development of prog...
متن کاملDevelopment and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study.
BACKGROUND The prognosis of early-onset pre-eclampsia (before 34 weeks' gestation) is variable. Accurate prediction of complications is required to plan appropriate management in high-risk women. OBJECTIVE To develop and validate prediction models for outcomes in early-onset pre-eclampsia. DESIGN Prospective cohort for model development, with validation in two external data sets. SETTING ...
متن کاملExternal validation, update and development of prediction models for pre-eclampsia using an Individual Participant Data (IPD) meta-analysis: the International Prediction of Pregnancy Complication Network (IPPIC pre-eclampsia) protocol
Background: Pre-eclampsia, a condition with raised blood pressure and proteinuria is associated with an increased risk of maternal and offspring mortality and morbidity. Early identification of mothers at risk is needed to target management. Methods/design: We aim to systematically review the existing literature to identify prediction models for pre-eclampsia. We have established the Internatio...
متن کاملMethodological issues in the development of a prediction model for pre-eclampsia complications
PREP (Prediction of risks in early onset pre-eclampsia) is a multicentre prospective cohort study aiming to develop and validate a prediction model in women admitted with early-onset pre-eclampsia for risk of adverse maternal outcome at 48 hours and until discharge. The primary outcome was a composite of adverse maternal outcomes and the secondary outcome a composite of adverse fetal outcomes. ...
متن کامل